According to ConsoleXP.com, the Uncharted series is the best PS3 exclusive of all time.
Well there has been no other PS3 exclusive that I've played as much as any one of the Uncharted titles, so yeah I'd cheerfully agree with that! That said, I may be a tiny bit biased...!
I like inFamous almost as much, but it isn't as popular or successful as Uncharted. If your just talking PS3, then I'd definitely agree that Uncharted is the greatest exclusive. But if your talking all of Playstation, then I might say Crash Bandicoot or God of War
Uncharted 1,2,and 3 are the best PS3 exclusives, Why?:
1) It has twists and turns everywhere
2) It has puzzles and shooting in every chapter
3) Graphics are amazing
4) Is very realistic (which I think is good but in real life you can not jump off buildings or get blown up and heal in three seconds)
5) It has different difficulties :Easy, Normal/Medium,Hard, and Crushing
6) There are stealth missions to full out kill zombie wars
7) There are zombies (remains of Sir Francis Drake's crew) and more zombies the 2nd (remains of Marco Polo's crew) and in the third one, djinns "born from smokeless fire"
8) Characters are easy to recognize and memorize
That is all I got