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It will probably take just as much, if not, more space than U3.
It depends how big this Lou person is.
The game will fill a double layer blu-ray disc so 50gb.
AKyemeni wrote:^ Not confirmed
I looked up and think UC3 ended up being around 45gb so i wouldnt be surprised if TLOU ison 2 discs (1 dual 1 single),