I just beat Soul Sacrifice and my save file got corrupted, I didn't mind as I didn't invest that much time to it, but then I replayed it again, and now, only 30 minutes in(thankfully only 30 minutes in), the save file got corrupted again, and it wasn't able to autosave.
It could be a defect in the game. Did you install the day 1 patch for the game? It could also be a problem with your memory card. Backing up the memory card with the Content Manager, and then reformatting the card, may solve the problem.