well, in real life, it would probably be Nathan Drake. Sweet Tooth's head would catch on fire, Kratos' weapons would not exist, same with Nariko, Sir Dan's bones would be too weak, and not stay together after one punch, and he would be a skeleton so he couldnt fight. Raiden wouldn't be able to react/attack fast enough since hes a cyborg, spike is a child, parappa is a dog, Heihachi and Cole wouldnt be able to withstand bullets. Heihachi might have a chance if he reacted fast enough.
But nathan has guns, not trying to say that guns are the ultimate weapon, but everyone else would have nothing. So if he shot at the right people first, he would probably win. Dante would be weighed down by the huge **bleep** sword on his back.
And thats why Drake would win in real life