Then zombies take over the backround running around and eating people. Then a robbery goes on having the robbers throw the money into the cart and then drives through where the characters are fighting running over the fighters. Then have a gang go through the town lassoing one player and taking him out of the map. Then a train drives through as well... Pretty obvious kill..
Maybe we could have Aku Aku from Crash as a pickup that allows for invulnerability.
A dragon egg from Spyro 3 that hatches a baby dragon who will fight for you.
A king lum from Rayman Origins which doubles all the... orb... thingie's value temporarily.
Just a few item ideas I had.