Chrono Trigger (SNES version), hands down, second favorite was most likely FF7.
the original Oregon Trail anyone??
I used to name my "family" after people I didn't like and watch them die of snake bites and dysentery....... not that I knew what dysentery was when I was 10......
I was also a fan of Roller Coaster Tycoon hehe
but it just didn't get any better than this: