Males: Booker Dewitt, Cole MacGrath, Zeke Dunbar, Trevor Phillips, Micheal De Santa, Franklin, Ben Paul, Lee Everett, Ethan Mars, Andrew Ryan, John marston, Jack Marston, Joel, Jaune Arc, Cardon Winchester, Lie Ren, and Professor Ozpin Females: Elizabeth, Jodie Holmes, Ellie, Yang xio Long, Ruby rose, Nora Valkyrie, Blake Belladona, Weiss Schnee, Glynda Goodwitch, and Pyrrah Nikos. Unconfirmed: Big Daddy.
Edit: Removed a spoilery bit.
I can't say I have any solid favorites, but Mario made a big impact on me when I was younger.
Of course Ellie from TLoU has my vote under female. She could of still had a huge impact even without Joel I think.
1.Isaac Clarke(Dead Space)-just a regular man with no super powers fighting hoards of monsters.
2.Garrus Vakarian(Mass Effect)-the baddest Turian of all time and no one better to have your back.
3.The new recruit Marine(Doom 3/BFG)-just arrives and has no idea what he's about to get into
4.Max Payne-tormented by his wifes death and constant need for pills and booze but a badazz none the less.
5.Serious Sam-saving the world one Mental at a time
1.Commander Shepard(female)-Jennifer Hale and Biotics have made this female my favorite heroine ever.
2.Maya(Borderlands 2)-from her crazy outfits to her awesome powers i would def bring her home to meet mom.
3.Seraphim(Sacred 2)-pure awesomeness and she rides around on a Sabertooth Tiger..don't get much better than that.
4.Xian Mei(Dead Island)-from resort employee one day to kicking zombies in the face and slicing them up the next.
5.Bastilia(Star Wars KotOR)-props to Jennifer Hale again..Bastilila was always so proper but quick to slice people into pieces as well..great balance.
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Favorite female game character: Ellie from The Last of Us. Why? She was the most flushed out and realistic female character I've ever come across. Her emotions made The Last of Us imo.
Favorite male game character: The End from Metal Gear: Snake Eater. Why? Best Boss Ever.