It can mean almost anything if you inflect the word properly.
This! Haha, my thoughts exactly.
As a Californian, so can "Dude"
*Friend punches a kid in the face*
"Dude...not cool man"
*Friend announces great news regarding his girlfriend staus*
*Dude steals your Dorito Taco when you go to wash your hands*
Welcoming Committee- "The business of gaming is business"