I'll admit to not owning the Sony 3D Display but I do have a 55" LED 3D TV, when I first got it I wondered about the best settings for that too, both 3D & otherwise, but you know what, after a while I realized the picture was damn good, both "normal TV & 3D TV, so i stopped trying to tweak so much & became happy with the picture.
Sometimes there are way too many settings on modern TV's which can make it so confusing for people, in a nutshell I would say of you're happy with what you're seeing then leave it alone, if you're not, then reset it back to factory settings & start again.
My 3D Display doesn't flicker, but I know some glasses do show a slight flicker sometimes, some say this is normal & others find it a little annoying, again it's a personal thing really.
From my experience no need to have seperate settings for 3d and 2d, other than for brightness. The cross talk thing was almost gone when i removed the clear film at the bottom of the screen(its explains in the manual.
These are my settings:
Picture>Backlight 2 or 10(2d/3d)
>Picture mode- dynamic
>brightness- 45
>contrast- 100
>Color- 60
>Hue- 0
Sharpness- 0
Color -Cool
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