I couldn't find anything about this. So here goes...
I've been playing Fallout 3 GOTY last few days and it was all good 'till now. My PS3 simply doesn't reconizes the disc and there's simply no way to access the game.
1- It's not scratched, I looked very closely for any physical damage on the disc and it was working perfectly before.
2- I thought my BD Drive was a goner but the other discs work (the ones I tried at least). My BD Data Utility is clean.
3- Last time I've played it, I quit game pressing PS button and then installed Bioshock 2 which I only started to see if there were any updates. Logout and Turn Off System from XMB.
PLZ HEELP !!
You don't have access to another PS3 do you?
Aside from it being a problem with the disc or the PS3, the only other thing I can think of is a regional coding problem. Where did you get game from?
It's from UK. But I don't think that's the problem since other UK games are still working.
Besides I've played Fallout 3 that day during morning but when I came back home by evening I simply couldn't find it where is was supposed to. You know XMB>Games>Disc Game.
The disc was inside the console all day long.
Sounds like a hardware issue to me. I had a similiar experience which ended with a busted disc drive.
Try asking around the PS3 General forum, they may know more: http://community.us.playstation.com/community/supp