I dont think desmond is dead. His body might be dead but is mind i think isnt. Maybe in the next game desmond will be like clay whos mind was trapped in the animus helping the new assassin.
you might want to put spoilers in your title just so people are aware. as for my personal opinion i have no idea! i don't think he's dead maybe in a coma at most.. i wouldn't think they would kill Desmond off
They said time and time again that this was the "end of Desmon's story." Sooo my prediciton is this..... AC 4 or AC3.2 or whatever desmond will be a "guide" like minerva or whatever.
I see the main stroyline taking place in modern time with a new assassin. Hopefully one we will like. with him still making trips into the animus but to different specific points in time as more than one assassin. I forsee a civil war missioin, vietnam, cuban missle crisis, things along that line that suppliment the current modern main story line.
Need ideas ubisoft? Give me a call.